Publications

The MEI trial evaluating ME-344, an investigational therapy demonstrated promising results in patients with advanced solid tumors. The trial assessed the safety and efficacy of ME-344, a mitochondrial inhibitor, in patients with various cancer types, including endometrial, ovarian, and breast cancers. The primary endpoint of the study was to determine the overall response rate (ORR), and secondary endpoints included progression-free survival (PFS) and overall survival (OS).

More than half of colorectal tumors harbor activating mutations in RAS/RAF proteins. Selumetinib (AZD6244, ARRY-142886) is a small molecule kinase inhibitor targeting MEK kinase, downstream of RAS. We examined the efficacy and safety of selumetinib with irinotecan in second-line therapy. 

Multi-tyrosine kinase inhibitors have shown clinical activity in metastatic colorectal cancer patients. Cabozantinib, a multi-tyrosine kinase inhibitor, exhibited potent antitumor activity superior to regorafenib in preclinical colorectal cancer patient-derived tumor xenograft models. This Phase II study aimed to investigate cabozantinib, a multityrosine kinase inhibitor, in refractory, metastatic colorectal cancer patients.

For many years colorectal cancer (CRC) has been one of the leading causes of cancer-related mortality worldwide and is currently the third-leading cause of death among all cancers in the United States. In 2020, the estimated number of new cases of colorectal cancer nationwide is 104,610, while the number of deaths it causes is projected to exceed 50,000.